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4224-69-5

  • Product NameMethyl 2-(bromomethyl)acrylate
  • Molecular FormulaC5H7BrO2
  • Molecular Weight179.013
  • Purity99%
  • AppearanceClear colorless to slightly yellow liquid
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Product Details

Quick Details

  • CasNo: 4224-69-5
  • Molecular Formula: C5H7BrO2
  • Appearance: Clear colorless to slightly yellow liquid
  • Purity: 99%

Chinese Factory Supply Best Quality Methyl 2-(bromomethyl)acrylate 4224-69-5 with Fast Shipping

  • Molecular Formula:C5H7BrO2
  • Molecular Weight:179.013
  • Appearance/Colour:Clear colorless to slightly yellow liquid 
  • Vapor Pressure:0.641mmHg at 25°C 
  • Refractive Index:n20/D 1.490(lit.)  
  • Boiling Point:187.1 °C at 760 mmHg 
  • Flash Point:59.9 °C 
  • PSA:26.30000 
  • Density:1.459 g/cm3 
  • LogP:1.11050 

Methyl 2-(bromomethyl)acrylate(Cas 4224-69-5) Usage

Chemical Properties

Clear colorless to slightly brownish liquid

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 7, p. 319, 1990Synthetic Communications, 16, p. 387, 1986 DOI: 10.1080/00397918608057713

InChI:InChI=1/C5H7BrO2/c1-4(3-6)5(7)8-2/h1,3H2,2H3

4224-69-5 Relevant articles

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Dunham,D.J.,Lawton,R.G.

, p. 2074 - 2075 (1971)

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Preparation of tetrasubstituted olefins using mono or double aerobic direct C-H functionalization strategies: Importance of steric effects

Gigant, Nicolas,Quintin, Franc?ois,B?ckvall, Jan-E.

, p. 2796 - 2803 (2015)

A novel protocol for the synthesis of te...

Copper-catalyzed radical oxyallylation of olefins for the construction of alkene-containing isoxazolines

He, Xiaoxue,Qian, Lijie,Dai, Yuyu,Yan, Xinhuan,Li, Xiaoqing,Xu, Xiangsheng

supporting information, (2021/05/31)

A radical-mediated approach to alkene ox...

Reaction type ultraviolet light absorber and preparation method and application thereof

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Paragraph 0047-0049, (2020/07/03)

The invention discloses a reaction type ...

COMPOSITIONS AND METHODS FOR PROTEIN LABELING, MODIFICATION, ANALYSIS, AND TARGETED DELIVERY

-

Paragraph 00218, (2020/01/24)

The invention relates to chemically reac...

Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem-Difluoroalkenes

Liu, Haidong,Ge, Liang,Wang, Ding-Xing,Chen, Nan,Feng, Chao

supporting information, p. 3918 - 3922 (2019/02/19)

A novel strategy for the expedient const...

4224-69-5 Process route

methyl 2-hydroxymethylacrylate
15484-46-5

methyl 2-hydroxymethylacrylate

methyl 2-(bromomethyl)propenoate
4224-69-5

methyl 2-(bromomethyl)propenoate

Conditions
Conditions Yield
With phosphorus tribromide; In diethyl ether; Inert atmosphere;
89%
With phosphorus tribromide; In diethyl ether; at 0 - 20 ℃; for 2h;
87.4%
With phosphorus tribromide; In acetonitrile; at 20 ℃; for 4h;
86%
With phosphorus tribromide; In diethyl ether; at 20 ℃; for 2h;
83%
With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃;
82%
With hydrogen bromide; acetic acid; at 25 ℃; Inert atmosphere;
79%
With hydrogen bromide; acetic acid; at 20 ℃; Inert atmosphere;
79%
With sulfuric acid; hydrogen bromide;
76%
With phosphorus tribromide; In dichloromethane; at 0 ℃; for 2.25h; Inert atmosphere;
72%
With 1H-imidazole; bromine; triphenylphosphine; In dichloromethane; at 0 ℃; for 0.333333h;
68%
With phosphorus tribromide; In diethyl ether; at -20 - 20 ℃; Inert atmosphere;
62%
With phosphorus tribromide; In diethyl ether; for 3h; Yield given; Ambient temperature;
 
Multi-step reaction with 2 steps
1: during storage at low temperature
2: 76 percent / HBr, H2SO4
With sulfuric acid; hydrogen bromide;
 
With sulfuric acid; hydrogen bromide; at 0 ℃; for 0.166667h;
 
With sulfuric acid; hydrogen bromide;
 
With sulfuric acid; hydrogen bromide;
 
With phosphorus tribromide; In diethyl ether; at 0 ℃; for 1h; Inert atmosphere;
 
With phosphorus tribromide; In diethyl ether; at -5 ℃;
 
With sulfuric acid; hydrogen bromide; at 0 ℃; for 0.25h;
 
With phosphorus tribromide; In diethyl ether; at 20 ℃; for 3h; Inert atmosphere; Cooling;
 
With hydrogen bromide; acetic acid;
 
With phosphorus tribromide; In diethyl ether; at 20 ℃; for 3h; Cooling; Inert atmosphere;
 
dimethylsulfide
75-18-3

dimethylsulfide

methyl 2-hydroxymethylacrylate
15484-46-5

methyl 2-hydroxymethylacrylate

methyl 2-(bromomethyl)propenoate
4224-69-5

methyl 2-(bromomethyl)propenoate

Conditions
Conditions Yield
With N-Bromosuccinimide; sodium chloride; In diethyl ether; dichloromethane;
89%

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