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16184-89-7

  • Product Name4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE
  • Molecular FormulaC8H4BrF3O
  • Molecular Weight253.018
  • Purity99%
  • Appearancepale yellow transparent liquid
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  • CasNo： 16184-89-7
  • Molecular Formula： C8H4BrF3O
  • Appearance： pale yellow transparent liquid
  • Purity： 99%

Chinese Manufacturer Supply Top Purity 99% 4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE 16184-89-7 On Stock

  • Molecular Formula:C8H4BrF3O
  • Molecular Weight:253.018
  • Appearance/Colour:pale yellow transparent liquid 
  • Vapor Pressure:0.0845mmHg at 25°C 
  • Melting Point:26-30 °C 
  • Refractive Index:1.449 
  • Boiling Point:239.891 °C at 760 mmHg 
  • Flash Point:98.883 °C 
  • PSA：17.07000 
  • Density:1.648 g/cm3 
  • LogP:3.19410 

4'-BROMO-2,2,2-TRIFLUOROACETOPHENONE(Cas 16184-89-7) Usage

Chemical Properties

Clear light yellow liquid

Uses

4?-Bromo-2,2,2-trifluoroacetophenone may be used in the preparation of carbonyl-bridged bithiazole derivatives. Also used as a reagent to synthesize MK-5046, a selective Bombesin receptor subtype-3 agonist used to treat obesity.

InChI:InChI=1/C10H9F3O/c1-2-9(14)7-5-3-4-6-8(7)10(11,12)13/h3-6H,2H2,1H3

16184-89-7 Relevant articles

Enantioselective Synthesis of Trifluoromethyl α,β-Unsaturated δ-Lactones via Vinylogous Aldol-Lactonization Cascade

Crotti, Simone,Di Iorio, Nicola,Mazzanti, Andrea,Righi, Paolo,Bencivenni, Giorgio

, p. 12440 - 12448 (2018)

The novel vinylogous aldol-lactonization...

Palladium-catalyzed carbonylative coupling of aryl iodides with an organocopper reagent: A straightforward procedure for the synthesis of aryl trifluoromethyl ketones

Zhu, Fengxiang,Yang, Guangfu,Zhou, Shaolin,Wu, Xiao-Feng

, p. 57070 - 57074 (2016)

A palladium-catalyzed carbonylative coup...

Photochemical C-H Activation Enables Nickel-Catalyzed Olefin Dicarbofunctionalization

Campbell, Mark W.,Yuan, Mingbin,Polites, Viktor C.,Gutierrez, Osvaldo,Molander, Gary A.

supporting information, p. 3901 - 3910 (2021/04/06)

Alkenes, ethers, and alcohols account fo...

Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Hiral spiro-fused bisoxazoline ligands with 1,1′-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction

Bao, Robert Li-Yuan,Fu, Kang,Shi, Lei

supporting information, (2021/11/27)

A novel class of chiral spiro-fused biso...

Synthesis of trifluoromethyl ketones by nucleophilic trifluoromethylation of esters under a fluoroform/KHMDS/triglyme system

Fujihira, Yamato,Liang, Yumeng,Ono, Makoto,Hirano, Kazuki,Kagawa, Takumi,Shibata, Norio

supporting information, p. 431 - 438 (2021/03/20)

A straightforward method that enables th...

Direct Synthesis of Tri-/Difluoromethyl Ketones from Carboxylic Acids by Cross-Coupling with Acyloxyphosphonium Ions

Ispizua-Rodriguez, Xanath,Munoz, Socrates B.,Krishnamurti, Vinayak,Mathew, Thomas,Prakash

supporting information, p. 15908 - 15913 (2021/10/07)

A simple and straightforward approach to...

16184-89-7 Process route

1-(4-bromo-phenyl)-2,2,2-trifluoro-ethanol
80418-12-8,80418-13-9,76911-73-4

1-(4-bromo-phenyl)-2,2,2-trifluoro-ethanol

4'-bromo-2,2,2-trifluoroacetophenone
16184-89-7

4'-bromo-2,2,2-trifluoroacetophenone

Conditions
Conditions Yield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; for 20h; Reflux;
96%
1-(4-bromo-phenyl)-2,2,2-trifluoro-ethanol; With N-(2,2,6,6-tetramethyl-1-oxopiperidin-1-ium-4-yl)acetamide tetrafluoroborate; In dichloromethane; at 20 ℃; for 0.0833333h;
With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃;
74%
With 9-azabicyclo[3.3.1]nonan-3-one N-oxyl oxide; oxygen; acetic acid; sodium nitrite; at 20 ℃; for 18h; under 760.051 Torr; chemoselective reaction;
65%
With tetra(n-butyl)ammonium hydrogen sulfate; In dichloromethane; water;
 
With 1,10-Phenanthroline; diethyl hydrazodicarboxylate; oxygen; potassium carbonate; copper(l) chloride; In toluene; at 90 ℃;
 
With dipyridinium dichromate; In dichloromethane; for 18h; Reflux; Inert atmosphere;
 
With sodium carbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 3h;
 
In dichloromethane; Reflux; Inert atmosphere;
795 mg
With 2,6-dimethylpyridine; N-(2,2,6,6-tetramethyl-1-oxopiperidin-1-ium-4-yl)acetamide tetrafluoroborate; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique;
 
With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 12h;
 
S-(tert-butyl)trifluorothioacetate
181820-18-8

S-(tert-butyl)trifluorothioacetate

4-Bromophenylboronic acid
5467-74-3

4-Bromophenylboronic acid

4'-bromo-2,2,2-trifluoroacetophenone
16184-89-7

4'-bromo-2,2,2-trifluoroacetophenone

Conditions
Conditions Yield
With tris-(dibenzylideneacetone)dipalladium(0); copper(I) thiophene-2-carboxylate; trifuran-2-yl-phosphane; In tetrahydrofuran; at 30 ℃; for 18h; Sealed tube; Inert atmosphere;
67%

16184-89-7 Upstream products

  • 383-63-1
    383-63-1

    ethyl trifluoroacetate,

  • 22480-64-4
    22480-64-4

    4-bromophenyllithium

  • 18620-02-5
    18620-02-5

    (4-bromophenyl)magnesium bromide

  • 407-25-0
    407-25-0

    trifluoroacetic anhydride

16184-89-7 Downstream products

  • 122243-28-1
    122243-28-1

    2‐(4‐bromophenyl)‐1,1,1‐trifluoropropan‐2‐ol

  • 80418-12-8
    80418-12-8

    1-(4-bromo-phenyl)-2,2,2-trifluoro-ethanol

  • 80418-12-8
    80418-12-8

    (R)-1-(4-bromophenyl)-2,2,2-trifluoroethanol

  • 76911-73-4
    76911-73-4

    (S)-1-(4-bromophenyl)-2,2,2-trifluoroethan-1-ol

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