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trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
(R)-Mandelic Acid
trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt
| Conditions | Yield |
|---|---|
|
trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid; With pyridine; thionyl chloride; In toluene; at 70 ℃; for 4h;
With sodium azide; tetrabutylammomium bromide; sodium carbonate; In water; toluene; at 0 ℃; for 2h;
(R)-Mandelic Acid; In ethyl acetate; at 17 - 25 ℃; for 3h;
|
82% |
(R)-Mandelic Acid
(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl carboxylic acid
trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt
| Conditions | Yield |
|---|---|
|
(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl carboxylic acid; With chloroformic acid ethyl ester; triethylamine; In water; acetone; for 1h;
(R)-Mandelic Acid; In ethanol; at 20 ℃; for 1h;
|
80% |
ortho-difluorobenzene
trans-(1R,2S)-2-(3,4-difluorophenyl)-1-nitrocyclopropane
(R)-Mandelic Acid
3-chloro-1-(3',4'-difluorophenyl)-propan-1-one
[3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol
tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate
ticagrelor
tert-butyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate
CAS：30827-99-7
CAS：145783-15-9
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