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97963-62-7

  • Product Name5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole
  • Molecular FormulaC8H6F2N2OS
  • Molecular Weight216.211
  • Purity99%
  • AppearancePale Yellow Solid
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Product Details

Quick Details

  • CasNo： 97963-62-7
  • Molecular Formula： C8H6F2N2OS
  • Appearance： Pale Yellow Solid
  • Purity： 99%

Quality Manufacturer Supply Buy High Quality 5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole 97963-62-7 with Efficient Shipping

  • Molecular Formula:C8H6F2N2OS
  • Molecular Weight:216.211
  • Appearance/Colour:Pale Yellow Solid 
  • Vapor Pressure:0.000928mmHg at 25°C 
  • Melting Point:239-243 °C(lit.) 
  • Refractive Index:1.63 
  • Boiling Point:303.5 °C at 760 mmHg 
  • PKA:9.77±0.30(Predicted) 
  • Flash Point:137.3 °C 
  • PSA：76.71000 
  • Density:1.52 g/cm3 
  • LogP:2.45300 

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole(Cas 97963-62-7) Usage

Chemical Properties

Pale Yellow Solid

Uses

Pantoprazole EP Impurity C. Pantoprazole USP Related Compound C.

General Description

5-(Difluoromethoxy)-2-mercapto-1H-benzimidazole may be used in the synthesis of pantoprazole, a drug for treating gastroesophageal reflux disease and gastrointestinal disorders.

InChI:InChI=1/C8H6F2N2OS/c9-7(10)13-4-1-2-5-6(3-4)12-8(14)11-5/h1-3,7H,(H2,11,12,14)

97963-62-7 Relevant articles

Synthesis and antimicrobial evaluations of sulfur inserted fluoro-benzimidazoles

Dwivedi, Parmesh Kumar,Chaturvedi, Devdutt

, p. 1525 - 1529 (2021/07/02)

A new series of fluorinated sulfur inser...

Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: Synthesis, in silico and cell growth inhibition studies

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, (2021/03/15)

An approach in modern medicinal chemistr...

Preparation method of 4- polyfluoro methoxy O-phenylenediamine (by machine translation)

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Paragraph 0015, (2020/01/03)

The method disclosed by the invention 4 ...

Triple Mode of Alkylation with Ethyl Bromodifluoroacetate: N, or O-Difluoromethylation, N-Ethylation and S-(ethoxycarbonyl)difluoromethylation

Polley, Arghya,Bairy, Gurupada,Das, Pritha,Jana, Ranjan

supporting information, p. 4161 - 4167 (2018/09/21)

In this report, we have explored a tripl...

97963-62-7 Process route

carbon disulfide
75-15-0,12122-00-8

carbon disulfide

4-(difluoromethoxy)benzene-1,2-diamine
172282-50-7

4-(difluoromethoxy)benzene-1,2-diamine

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

Conditions
Conditions Yield
4-(difluoromethoxy)benzene-1,2-diamine; With sodium carbonate; In water; for 0.333333h; Reflux; Green chemistry;
carbon disulfide; In water; at 25 - 70 ℃; for 12h; Temperature; Reagent/catalyst; Green chemistry;
95.4%
With sodium hydroxide; In methanol; for 4h; Reflux;
94.5%
With potassium hydroxide; In ethanol;
52%
With sodium carbonate; In water; at 20 - 70 ℃; for 12h;
77 mg
In ethanol; at 60 ℃; for 5h;
 
3,4-dinitophenol
577-71-9

3,4-dinitophenol

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole
97963-62-7

5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: caesium carbonate / N,N-dimethyl-formamide / 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C
3: sodium carbonate / water / 12 h / 20 - 70 °C
With palladium 10% on activated carbon; hydrogen; sodium carbonate; caesium carbonate; In methanol; water; N,N-dimethyl-formamide;
 

97963-62-7 Upstream products

  • 75-15-0
    75-15-0

    carbon disulfide

  • 172282-50-7
    172282-50-7

    4-(difluoromethoxy)benzene-1,2-diamine

  • 577-71-9
    577-71-9

    3,4-dinitophenol

  • 103-90-2
    103-90-2

    4-acetaminophenol

97963-62-7 Downstream products

  • 97964-24-4
    97964-24-4

    5-Difluoromethoxy-2-(4-methoxy-3-methyl-pyridin-2-ylmethylsulfanyl)-1H-benzoimidazole

  • 102625-64-9
    102625-64-9

    pantoprazole sulfide

  • 102625-62-7
    102625-62-7

    5-difluoromethoxy-2-[(4,5-dimethoxy-3-methyl-pyridin-2-yl)methylthio]-1H-benzimidazole

  • 953787-51-4
    953787-51-4

    5-(difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole

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