22536-67-0

  • Product Name2,5-Dichloropyrimidine
  • Molecular FormulaC4H2Cl2N2
  • Molecular Weight148.979
  • Purity99%
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Product Details

Quick Details

  • CasNo: 22536-67-0
  • Molecular Formula: C4H2Cl2N2
  • Purity: 99%

Quality Factory Supply Buy Reliable Quality 2,5-Dichloropyrimidine 22536-67-0 with Safe Shipping

  • Molecular Formula:C4H2Cl2N2
  • Molecular Weight:148.979
  • Vapor Pressure:0.0152mmHg at 25°C 
  • Melting Point:57.0-57.5 °C 
  • Refractive Index:1.559 
  • Boiling Point:265.3 °C at 760 mmHg 
  • PKA:-2.84±0.22(Predicted) 
  • Flash Point:139.8 °C 
  • PSA:25.78000 
  • Density:1.493 g/cm3 
  • LogP:1.78340 

2,5-Dichloropyrimidine(Cas 22536-67-0) Usage

Uses

2,5-Dichloropyrimidine acid is employed as a important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

InChI:InChI=1/C4H2Cl2N2/c5-3-1-7-4(6)8-2-3/h1-2H

22536-67-0 Relevant articles

Structure Analysis Restrained by ab Initio Calculations: The Molecular Structure of 2,5-Dichloropyrimidine in Gaseous and Crystalline Phases

Blake, Alexander J.,Brain, Paul T.,McNab, Hamish,Miller, Jennifer,Morrison, Carole A.,et al.

, p. 12280 - 12287 (1996)

A new method to obtain improved structur...

NOVEL COMPOUNDS AS GPR119 AGONISTS

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Paragraph 0511-0513, (2017/10/26)

The present invention relates to novel c...

Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection

Beaulieu, Pierre L.,Anderson, Paul C.,Bethell, Richard,B?s, Michael,Bousquet, Yves,Brochu, Christian,Cordingley, Michael G.,Fazal, Gulrez,Garneau, Michel,Gillard, James R.,Kawai, Stephen,Marquis, Martin,McKercher, Ginette,Poupart, Marc-André,Stammers, Timothy,Thavonekham, Bounkham,Wernic, Dominik,Duan, Jianmin,Kukolj, George

, p. 10130 - 10143 (2015/02/05)

The development of interferon-free regim...

SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS

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Page/Page column 43, (2013/06/05)

Substituted cyclopropyl compounds of the...

SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS

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Page/Page column 40, (2013/08/28)

Substituted cyclopropyl compounds of the...

22536-67-0 Process route

2,4,5-trichloropyrimidine
5750-76-5

2,4,5-trichloropyrimidine

2,5-dichloropyrimidine
22536-67-0

2,5-dichloropyrimidine

Conditions
Conditions Yield
2,4,5-trichloropyrimidine; With hydrogen; palladium 10% on activated carbon; In methanol; at 50 ℃; for 2h;
With sodium hydrogencarbonate; In methanol; water; at 20 ℃;
 
With acetic acid; zinc; In tetrahydrofuran; at 20 ℃; for 2h; Heating; Reflux;
 
With acetic acid; zinc; In tetrahydrofuran; for 2h; Reflux;
 
2,4,5-trichloropyrimidine; With acetic acid; zinc; In tetrahydrofuran; for 2h; Reflux;
With sodium hydrogencarbonate; sodium hydroxide; In dichloromethane; water; pH=10;
 
With acetic acid; zinc; In tetrahydrofuran; at 20 ℃; Reflux;
 
(2-chloropyrimidin-5-yl)boronic acid
1003845-06-4

(2-chloropyrimidin-5-yl)boronic acid

2,5-dichloropyrimidine
22536-67-0

2,5-dichloropyrimidine

Conditions
Conditions Yield
With N-chloro-succinimide; copper(l) chloride; In acetonitrile; at 80 ℃; for 16h;
75%

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