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882678-96-8

  • Product Name3-Amino-2-methylphenylboronic acid, pinacol ester
  • Molecular FormulaC13H20 B N O2
  • Molecular Weight233.118
  • Purity99%
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Product Details

Quick Details

  • CasNo： 882678-96-8
  • Molecular Formula： C13H20 B N O2
  • Purity： 99%

Factory Supply Buy Quality 3-Amino-2-methylphenylboronic acid, pinacol ester 882678-96-8 Customized Supply

  • Molecular Formula:C13H20 B N O2
  • Molecular Weight:233.118
  • Vapor Pressure:1.59E-05mmHg at 25°C 
  • Refractive Index:1.515 
  • Boiling Point:365.3°C at 760 mmHg 
  • PKA:4.44±0.10(Predicted) 
  • Flash Point:174.7°C 
  • PSA：44.48000 
  • Density:1.03g/cm3 
  • LogP:2.45760 

3-Amino-2-methylphenylboronic acid, pinacol ester(Cas 882678-96-8) Usage

General Description

3-Amino-2-methylphenylboronic acid, pinacol ester is a chemical compound that belongs to the class of boronic acids. It is an ester derivative of 3-amino-2-methylphenylboronic acid, with the pinacol moiety serving as the ester group. 3-Amino-2-methylphenylboronic acid, pinacol ester is commonly used in organic synthesis as a reagent for the construction of carbon-carbon and carbon-heteroatom bonds. It is also utilized in the development of pharmaceuticals and agrochemicals. Additionally, its reactivity and versatility make it a valuable building block for the preparation of various complex molecules in the fields of medicinal chemistry and materials science.

InChI:InChI=1/C13H20BNO2/c1-9-10(7-6-8-11(9)15)14-16-12(2,3)13(4,5)17-14/h6-8H,15H2,1-5H3

882678-96-8 Relevant articles

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882678-96-8 Process route

3-bromo-2-methylaniline
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bis(pinacol)diborane
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bis(pinacol)diborane

2-methyl-3-( 4,4,5,5-tetramethyl[1,3,2]dioxaborolane-2-yl)phenylamine
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2-methyl-3-( 4,4,5,5-tetramethyl[1,3,2]dioxaborolane-2-yl)phenylamine

Conditions
Conditions Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; at 110 ℃; for 2.75h; Inert atmosphere;
91%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; dimethyl sulfoxide; for 2h; Inert atmosphere; Reflux;
88%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; dimethyl sulfoxide; for 2h; Reflux; Inert atmosphere;
88%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; at 90 ℃; for 12h;
56.82%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 48h; Inert atmosphere;
39%
With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 22h;
39%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; at 120 ℃; for 2h;
 
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 16h; Inert atmosphere;
 
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane;
 
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 90 ℃; for 3h; Inert atmosphere;
 
2-(2-methyl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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2-(2-methyl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-methyl-3-( 4,4,5,5-tetramethyl[1,3,2]dioxaborolane-2-yl)phenylamine
882678-96-8

2-methyl-3-( 4,4,5,5-tetramethyl[1,3,2]dioxaborolane-2-yl)phenylamine

Conditions
Conditions Yield
With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 13h;
100%
With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 13h; Inert atmosphere;
100%
With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 13h; Product distribution / selectivity;
100%
With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 6h;
 
With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 13h;
 
With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 6h; Inert atmosphere;
3.12 g
With platinum(IV) oxide; hydrogen; In tetrahydrofuran; at 20 ℃;
 

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882678-96-8 Downstream products

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    5-(3-amino-2-methylphenyl)-3-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-1-methylpyrazin-2(1h)-one

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