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53188-07-1

  • Product Name6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
  • Molecular FormulaC14H18O4
  • Molecular Weight250.295
  • Purity99%
  • Appearancewhite to fainly beige crystalline powder
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Product Details

Quick Details

  • CasNo： 53188-07-1
  • Molecular Formula： C14H18O4
  • Appearance： white to fainly beige crystalline powder
  • Purity： 99%

Chinese Manufacturer Supply 99% Pure 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID53188-07-1 with Low Price

  • Molecular Formula:C14H18O4
  • Molecular Weight:250.295
  • Appearance/Colour:white to fainly beige crystalline powder 
  • Vapor Pressure:6.8E-09mmHg at 25°C 
  • Melting Point:187-189 °C(lit.) 
  • Refractive Index:1.4970 (estimate) 
  • Boiling Point:450.3 °C at 760mmHg 
  • PKA:3.35±0.20(Predicted) 
  • Flash Point:171 °C 
  • PSA：66.76000 
  • Density:1.219 g/cm3 
  • LogP:2.48570 

6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID(Cas 53188-07-1) Usage

Description

Trolox (53188-07-1) is a water soluble derivative of vitamin E. Displays antioxidant and radical scavenging activities.1 Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells.2 Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.3

Chemical Properties

white to fainly beige crystalline powder

Uses

Trolox is a Vitamin E analog that also maintains the antioxidant capabilities which Vitamin E shows.

Definition

ChEBI: A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capa ity of complex mixtures.

General Description

(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) exhibits radical scavenging and antioxidant activities.

InChI:InChI=1/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)/p-1/t14-/m1/s1

53188-07-1 Relevant articles

SYNTHESIS OF TOCOTRIENOLS FROM O-CRESOL DERIVATIVES

-

Page/Page column 40-41, (2019/04/11)

The present invention provides an enviro...

A green multicomponent synthesis of tocopherol analogues with antiproliferative activities

Ingold, Mariana,Dapueto, Rosina,Victoria, Sabina,Galliusi, Germán,Batthyàny, Carlos,Bollati-Fogolín, Mariela,Tejedor, David,García-Tellado, Fernando,Padrón, José M.,Porcal, Williams,López, Gloria V.

, p. 1888 - 1902 (2017/11/15)

A one-pot efficient, practical and eco-f...

POLYMORPHIC AND AMORPHOUS FORMS OF (R)-2-HYDROXY-2-METHYL-4-(2,4,5-TRIMETHYL-3,6-DIOXOCYCLOHEXA-1,4-DIENYL)BUTANAMIDE

-

Paragraph 0191, (2016/07/05)

Disclosed herein are polymorphic and amo...

Gold-catalyzed asymmetric allylic substitution of free alcohols: An enantioselective approach to chiral chromans with quaternary stereocenters for the synthesis of Vitamin E and analogues

Uria, Uxue,Vila, Carlos,Lin, Ming-Yuan,Rueping, Magnus

supporting information, p. 13913 - 13917 (2016/02/18)

The enantioselective synthesis of α- and...

53188-07-1 Process route

C<sub>56</sub>H<sub>98</sub>O<sub>35</sub>*C<sub>14</sub>H<sub>18</sub>O<sub>4</sub>

C56H98O35*C14H18O4

heptakis(2,6-di-O-methyl)cyclomaltoheptaose
51166-71-3

heptakis(2,6-di-O-methyl)cyclomaltoheptaose

trolox
56305-04-5,53188-07-1

trolox

Conditions
Conditions Yield
In water-d2; at 29.84 ℃; Equilibrium constant;
 
methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate
86646-83-5

methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate

trolox
56305-04-5,53188-07-1

trolox

Conditions
Conditions Yield
methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate; With sodium hydroxide; water; In methanol; at 80 ℃; for 2h;
With potassium hydrogensulfate; In methanol; water; at 80 ℃; for 2h;
99.3%
methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate; With water; sodium hydroxide; In methanol; at 80 ℃; for 1h; Inert atmosphere;
With potassium hydrogensulfate; water; In methanol; at 80 ℃;
98.3%
methyl 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylate; With sodium hydroxide; In methanol; at 80 ℃;
With potassium hydrogensulfate; In water; at 80 ℃;
65%

53188-07-1 Upstream products

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53188-07-1 Downstream products

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  • 122003-24-1
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    [4-(4-Chloro-phenyl)-piperazin-1-yl]-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-methanone

  • 122003-25-2
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    1-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)carbonyl]-4-(4-methoxyphenyl)piperazine

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    2-Hydroxy-2-methyl-4-(2,5,6-trimethyl-2,4-dioxo-2,5-cyclohexadienyl)butanoic acid

;

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