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The invention discloses a preparation me...
The invention provides a novel preparati...
![benzo[B]thiophen-4-ylamine](/upload/2024/4/d4e20b1e-9a2c-4892-98be-9857fe0cb158.png)
benzo[B]thiophen-4-ylamine


bis-(2-chloroethyl)amine hydrochloride

![1-(benzo[b]thiophen-4-yl)piperazine hydrochloride](/upload/2024/4/087fdef5-803a-425b-a577-20d03780e7ce.png)
1-(benzo[b]thiophen-4-yl)piperazine hydrochloride
| Conditions | Yield |
|---|---|
|
With toluene-4-sulfonamide; In 5,5-dimethyl-1,3-cyclohexadiene; at 120 - 150 ℃; for 16h;
|
85% |
|
With potassium carbonate; In butan-1-ol; for 24h; Reflux;
|
84% |
![1-(benzo[b]thiophen-4-yl)piperazine hydrochloride](/upload/2024/4/087fdef5-803a-425b-a577-20d03780e7ce.png)
1-(benzo[b]thiophen-4-yl)piperazine hydrochloride


7-(4-bromobutoxy-1,1,2,2,3,3,4,4-d8)-1H-quinolin-2-one

![7-[4-(4-benzo[b]thiophen-4-ylpiperazin-1-yl)butoxy-1,1,2,2,3,3,4,4-d<sub>8</sub>]-1H-quinolin-2-one](/upload/2024/4/4f87e9db-50b7-4e69-971f-6d1a12ee0b70.png)
7-[4-(4-benzo[b]thiophen-4-ylpiperazin-1-yl)butoxy-1,1,2,2,3,3,4,4-d8]-1H-quinolin-2-one
| Conditions | Yield |
|---|---|
|
With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 6h;
|
0.3 g |
|
With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 6h;
|
0.3 g |

benzo[B]thiophen-4-ylamine

bis-(2-chloroethyl)amine hydrochloride

7-[4-(4-benzo[b]thiophen-4-ylpiperazin-1-yl)butoxy-1,1,2,2,3,3,4,4-d8]-1H-quinolin-2-one
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