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573762-62-6

  • Product Name5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE
  • Molecular FormulaC7H4 F3N3
  • Molecular Weight187.124
  • Purity99%
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Product Details

Quick Details

  • CasNo： 573762-62-6
  • Molecular Formula： C7H4 F3N3
  • Purity： 99%

Chinese Factory Supply Buy Quality 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE 573762-62-6 Customized Supply

  • Molecular Formula:C7H4 F3N3
  • Molecular Weight:187.124
  • Boiling Point:362.2±42.0 °C(Predicted) 
  • PKA:-1.52±0.10(Predicted) 
  • PSA：62.70000 
  • Density:1.45±0.1 g/cm3(Predicted) 
  • LogP:2.13548 

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573762-62-6 Process route

2-cyano-3-(trifluoromethyl)-5-nitropyridine
573762-57-9

2-cyano-3-(trifluoromethyl)-5-nitropyridine

5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile
573762-62-6

5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

Conditions
Conditions Yield
With hydrogenchloride; iron; In water; ethyl acetate; Reflux;
95%
With iron; acetic acid; In ethyl acetate; for 15h; Reagent/catalyst;
91%
With iron; acetic acid; In ethyl acetate; for 15h; Heating;
91%
With hydrogen; In ethanol; under 1520.1 Torr; Autoclave;
90%
With iron; acetic acid; In ethyl acetate; at 65 ℃; for 2h; Product distribution / selectivity;
67%
With iron; acetic acid; In ethyl acetate; Reflux;
54.5%
With iron; acetic acid; In ethyl acetate; for 16h; Inert atmosphere; Reflux;
54%
 
  
With ammonium vanadate; platinum on carbon; hydrogen; hypophosphorous acid; In 5,5-dimethyl-1,3-cyclohexadiene; water; at 70 ℃; for 1.5h; under 3750.38 Torr; Autoclave;
 
With iron; acetic acid; In ethyl acetate; for 15h; Reflux;
0.8 g
5-{[(4-methoxyphenyl)methyl]amino}-3-(trifluoromethyl)pyridine-2-carbonitrile
956104-45-3

5-{[(4-methoxyphenyl)methyl]amino}-3-(trifluoromethyl)pyridine-2-carbonitrile

5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile
573762-62-6

5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

Conditions
Conditions Yield
With trifluoroacetic acid; In dichloromethane;
95%
With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Product distribution / selectivity;
85%
With trifluoroacetic acid; In dichloromethane; at 10 ℃; for 2h;
 
With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
 

573762-62-6 Upstream products

  • 573762-57-9
    573762-57-9

    2-cyano-3-(trifluoromethyl)-5-nitropyridine

  • 956104-45-3
    956104-45-3

    5-{[(4-methoxyphenyl)methyl]amino}-3-(trifluoromethyl)pyridine-2-carbonitrile

  • 887707-23-5
    887707-23-5

    2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine

  • 887707-25-7
    887707-25-7

    2-chloro-5-iodo-3-(trifluoromethyl)pyridine

573762-62-6 Downstream products

  • 956104-40-8
    956104-40-8

    ARN-509

  • 1332391-11-3
    1332391-11-3

    4-[6-[6-cyano-5-(trifluoromethyl)-3-pyridyl]-5-oxo-7-thioxo-6,8-diazaspiro[3.4]octan-8-yl]-2-fluorobenzamide

;

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