What is the 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE?

5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE is , while it's Molecular Formula is C7H4 F3N3. 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE is a pyridine heterocyclic organic compound, which can be used as pharmaceutical intermediates.

What is the CAS number for 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE?

The CAS number of 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE is 573762-62-6.

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Product Details

Quick Details

CasNo： 573762-62-6
Molecular Formula： C₇H₄ F₃N₃
Purity： 99%

Chinese Factory Supply Buy Quality 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE 573762-62-6 Customized Supply

Molecular Formula:C7H4 F3N3
Molecular Weight:187.124
Boiling Point:362.2±42.0 °C(Predicted)
PKA:-1.52±0.10(Predicted)
PSA：62.70000
Density:1.45±0.1 g/cm3(Predicted)
LogP:2.13548

573762-62-6 Relevant articles

Discovery of pyridine tetrahydroisoquinoline thiohydantoin derivatives with low blood-brain barrier penetration as the androgen receptor antagonists

Bian, Jinlei,Chen, Xijing,Du, Qianming,Ge, Raoling,Li, Yan,Li, Zhiyu,Lu, Xiaoyu,Meng, Ying,Wang, Jubo,Wu, Hongxi,Xu, Xi,Xue, Siqi,Yang, Yong,Zhao, Zhili

, (2020/03/11)

Prostate cancer (PC) is the most diagnos...

DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST

-

Paragraph 0474; 0483-0484, (2020/07/07)

The present application belongs to the f...

Preparation method of 5 - (S)-3 -(trifluoromethyl) pyrimidin -2 -one (trifluoromethyl) pyridylketone (I) (by machine translation)

-

Paragraph 0031; 0034, (2019/10/01)

The method comprises the following three...

Prostatic cancer treatment medicine

-

Paragraph 0019-0020; 0027-0028, (2019/03/26)

The invention relates to a compound with...

573762-62-6 Process route

: 573762-57-9
2-cyano-3-(trifluoromethyl)-5-nitropyridine

: 573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

Conditions

Conditions	Yield
With hydrogenchloride; iron; In water; ethyl acetate; Reflux;	95%
With iron; acetic acid; In ethyl acetate; for 15h; Reagent/catalyst;	91%
With iron; acetic acid; In ethyl acetate; for 15h; Heating;	91%
With hydrogen; In ethanol; under 1520.1 Torr; Autoclave;	90%
With iron; acetic acid; In ethyl acetate; at 65 ℃; for 2h; Product distribution / selectivity;	67%
With iron; acetic acid; In ethyl acetate; Reflux;	54.5%
With iron; acetic acid; In ethyl acetate; for 16h; Inert atmosphere; Reflux;	54%

With ammonium vanadate; platinum on carbon; hydrogen; hypophosphorous acid; In 5,5-dimethyl-1,3-cyclohexadiene; water; at 70 ℃; for 1.5h; under 3750.38 Torr; Autoclave;
With iron; acetic acid; In ethyl acetate; for 15h; Reflux;	0.8 g

: 956104-45-3
5-{[(4-methoxyphenyl)methyl]amino}-3-(trifluoromethyl)pyridine-2-carbonitrile

: 573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

Conditions

Conditions	Yield
With trifluoroacetic acid; In dichloromethane;	95%
With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Product distribution / selectivity;	85%
With trifluoroacetic acid; In dichloromethane; at 10 ℃; for 2h;
With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

573762-62-6 Upstream products

573762-57-9
2-cyano-3-(trifluoromethyl)-5-nitropyridine
956104-45-3
5-{[(4-methoxyphenyl)methyl]amino}-3-(trifluoromethyl)pyridine-2-carbonitrile
887707-23-5
2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine
887707-25-7
2-chloro-5-iodo-3-(trifluoromethyl)pyridine

573762-62-6 Downstream products

956104-40-8
ARN-509
1332391-11-3
4-[6-[6-cyano-5-(trifluoromethyl)-3-pyridyl]-5-oxo-7-thioxo-6,8-diazaspiro[3.4]octan-8-yl]-2-fluorobenzamide

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573762-62-6

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Chinese Factory Supply Buy Quality 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE 573762-62-6 Customized Supply

573762-62-6 Relevant articles

Discovery of pyridine tetrahydroisoquinoline thiohydantoin derivatives with low blood-brain barrier penetration as the androgen receptor antagonists

Bian, Jinlei,Chen, Xijing,Du, Qianming,Ge, Raoling,Li, Yan,Li, Zhiyu,Lu, Xiaoyu,Meng, Ying,Wang, Jubo,Wu, Hongxi,Xu, Xi,Xue, Siqi,Yang, Yong,Zhao, Zhili

, (2020/03/11)

DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST

-

Paragraph 0474; 0483-0484, (2020/07/07)

Preparation method of 5 - (S)-3 -(trifluoromethyl) pyrimidin -2 -one (trifluoromethyl) pyridylketone (I) (by machine translation)

-

Paragraph 0031; 0034, (2019/10/01)

Prostatic cancer treatment medicine

-

Paragraph 0019-0020; 0027-0028, (2019/03/26)

573762-62-6 Process route

573762-62-6 Upstream products

573762-62-6 Downstream products

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