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50-91-9

  • Product NameFloxuridine
  • Molecular FormulaC9H11FN2O5
  • Molecular Weight246.195
  • Purity99%
  • Appearancewhite solid
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  • CasNo： 50-91-9
  • Molecular Formula： C9H11FN2O5
  • Appearance： white solid
  • Purity： 99%

Chinese Manufacturer Supply Buy High Grade Floxuridine 50-91-9 On Stock

  • Molecular Formula:C9H11FN2O5
  • Molecular Weight:246.195
  • Appearance/Colour:white solid 
  • Melting Point:148 °C(lit.) 
  • Boiling Point:150 °C 
  • PKA:pKa 7.44 (Uncertain) 
  • PSA：104.55000 
  • Density:1.64 g/cm3 
  • LogP:-1.68360 

50-91-9 Relevant articles

Activation of antibacterial prodrugs by peptide deformylase

Wei, Yaoming,Pei, Dehua

, p. 1073 - 1076 (2000)

5'-Dipeptidyl derivatives of 5-fluorodeo...

In vitro drug release from macromolecule-drug conjugates of 3'-(7-carboxyheptanoyl)-5-fluoro-2'-deoxyuridine with decylenediamine-dextran T70 of poly-L-lysine

Onishi,Kawaguchi,Nagai

, p. 3370 - 3374 (1987)

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Floxuridine Oligomers Activated under Hypoxic Environment

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Floxuridine oligomers are anticancer oli...

Biotransformation of halogenated 2′-deoxyribosides by immobilized lactic acid bacteria

Britos, Claudia N.,Cappa, Valeria A.,Rivero, Cintia W.,Sambeth, Jorge E.,Lozano, Mario E.,Trelles, Jorge A.

, p. 49 - 53 (2012)

An efficient and green bioprocess is her...

Thermodynamic Reaction Control of Nucleoside Phosphorolysis

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, p. 867 - 876 (2020/01/24)

Nucleoside analogs represent a class of ...

FLOXURIDINE SYNTHESIS

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Page/Page column 33-34, (2019/04/11)

The present invention relates to a proce...

Bio-catalytic synthesis of unnatural nucleosides possessing a large functional group such as a fluorescent molecule by purine nucleoside phosphorylase

Hatano, Akihiko,Wakana, Hiroyuki,Terado, Nanae,Kojima, Aoi,Nishioka, Chisato,Iizuka, Yu,Imaizumi, Takuya,Uehara, Sanae

, p. 5122 - 5129 (2019/10/05)

Unnatural nucleosides are attracting int...

50-91-9 Process route

5-fluorouracil
51-21-8

5-fluorouracil

thymidine
50-89-5,28854-96-8,3545-96-8,50-88-4

thymidine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
Conditions Yield
With Lactobacillus animalis ATCC 35046 2’-N-deoxyribosyltransferase immobilized in DEAE-Sepharose; In aq. buffer; at 30 ℃; pH=7; Concentration; Reagent/catalyst; Green chemistry; Enzymatic reaction;
35%
With thymidine phosphorylase; In aq. phosphate buffer; at 37 ℃; for 0.2h; pH=6.8; Enzymatic reaction;
 
With ammonium dihydrogen phosphate; ammonia; In water; at 45 - 55 ℃; for 45h; pH=6.6; Large scale; Enzymatic reaction;
 
With recobinant purine nucleoside phosphorylase from Escherichia coli; In aq. phosphate buffer; pH=6.8; Heating; Enzymatic reaction;
 
3',5'-di-O-(p-chlorobenzoyl)-5-fluoro-2'-deoxy-β-uridine
1582-79-2,110558-30-0

3',5'-di-O-(p-chlorobenzoyl)-5-fluoro-2'-deoxy-β-uridine

5-Fluoro-2'-deoxyuridine
50-91-9

5-Fluoro-2'-deoxyuridine

Conditions
Conditions Yield
With methanol; ammonia; at 10 - 25 ℃;
86.2%
With ammonia; In methanol; at 30 ℃; for 16h;
 
With methanol; barium methoxide;
 

50-91-9 Upstream products

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    5-fluoro-O3',O5'-bis-(4-methyl-benzoyl)-2'-deoxy-uridine

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    3',5'-di-O-(p-chlorobenzoyl)-5-fluoro-2'-deoxy-β-uridine

  • 951-78-0
    951-78-0

    2'-deoxyuridine

  • 78948-09-1
    78948-09-1

    acetyl hypofluorite

50-91-9 Downstream products

  • 2823-52-1
    2823-52-1

    5'-O-acetyl-floxuridine

  • 7207-56-9
    7207-56-9

    Acetic acid (2R,3S)-2-acetoxymethyl-5-((S)-5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

  • 2059-38-3
    2059-38-3

    3′-O-acetyl-5-fluoro-2′-deoxyuridine

  • 104495-48-9
    104495-48-9

    1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione

;

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