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452-71-1

  • Product Name4-Fluoro-2-methylaniline
  • Molecular FormulaC7H8FN
  • Molecular Weight125.146
  • Purity99%
  • Appearancecolorless to light yellow liquid
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Product Details

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  • CasNo： 452-71-1
  • Molecular Formula： C7H8FN
  • Appearance： colorless to light yellow liquid
  • Purity： 99%

Factory Supply High Purity Top Purity 4-Fluoro-2-methylaniline 452-71-1 with Efficient Transportation

  • Molecular Formula:C7H8FN
  • Molecular Weight:125.146
  • Appearance/Colour:colorless to light yellow liquid 
  • Vapor Pressure:0.231mmHg at 25°C 
  • Melting Point:14oC 
  • Refractive Index:n20/D 1.537(lit.)  
  • Boiling Point:206.9 °C at 760 mmHg 
  • PKA:4.51±0.10(Predicted) 
  • Flash Point:87.8 °C 
  • PSA：26.02000 
  • Density:1.115 g/cm3 
  • LogP:2.29750 

4-Fluoro-2-methylaniline(Cas 452-71-1) Usage

Chemical Properties

colorlesstolightyellowliqui

Uses

4-Fluoro-2-methylaniline was used in the synthesis of 4-fluoro-N-[(E)-{7-methoxy-2-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}methylidene]-2-methylaniline.

InChI:InChI=1/C7H8FN/c1-5-4-6(8)2-3-7(5)9/h2-4H,9H2,1H3

452-71-1 Relevant articles

4 - Fluorine substituted aryl amine compound and synthesis method thereof

-

Paragraph 0054-0056, (2021/09/22)

The invention discloses a synthesis meth...

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

Teo, Theodosia,Yang, Yuchao,Yu, Mingfeng,Basnet, Sunita K.C.,Gillam, Todd,Hou, Jinqiang,Schmid, Raffaella M.,Kumarasiri, Malika,Diab, Sarah,Albrecht, Hugo,Sykes, Matthew J.,Wang, Shudong

, p. 539 - 550 (2015/10/12)

Deregulation of protein synthesis is a c...

Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection

Walia, Amit,Kang, Soosung,Silverman, Richard B

, p. 10931 - 10937 (2013/11/19)

Primary amines can be readily doubly pro...

Efficient indoles and anilines syntheses employing tert-butyl sulfinamide as ammonia surrogate

Prakash, Anjanappa,Dibakar, Mullick,Selvakumar, Kumaravel,Ruckmani, Kandasamy,Sivakumar, Manickam

supporting information; experimental part, p. 5625 - 5628 (2011/11/06)

tert-Butyl sulfinamide is an ammonia equ...

452-71-1 Process route

N-(4-fluoro-2-methylphenyl)-2-methylpropane-2-sulfinamide
1338209-86-1

N-(4-fluoro-2-methylphenyl)-2-methylpropane-2-sulfinamide

4-fluor-2-methylaniline
452-71-1

4-fluor-2-methylaniline

Conditions
Conditions Yield
N-(4-fluoro-2-methylphenyl)-2-methylpropane-2-sulfinamide; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.25h; Inert atmosphere;
With sodium hydrogencarbonate; In 1,4-dioxane; water; Inert atmosphere;
96%
m-Fluorotoluene
352-70-5

m-Fluorotoluene

5-Fluoro-2-nitrotoluene
446-33-3

5-Fluoro-2-nitrotoluene

4-fluor-2-methylaniline
452-71-1

4-fluor-2-methylaniline

Conditions
Conditions Yield
With nitric acid; palladium; In ice-water; ethanol; hydrogen;
 

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