What is the 4-PHENOXYBENZOIC ACID?

4-PHENOXYBENZOIC ACID is white to slightly yellow crystalline powder, while it's Molecular Formula is C13H10O3. white to slightly yellow crystalline powder 4-Phenoxybenzoic acid can block DNA binding of the human papillomarvirus (HPV) E2 protein. It is employed as an intermediate of Sitafloxacin, which is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer.

What is the CAS number for 4-PHENOXYBENZOIC ACID?

The CAS number of 4-PHENOXYBENZOIC ACID is 2215-77-2.

Reputable Manufacturer Supply Reliable Quality 4-PHENOXYBENZOIC ACID 2215-77-2 with Safe Shipping

Product Details

Quick Details

CasNo： 2215-77-2
Molecular Formula： C₁₃H₁₀O₃
Appearance： white to slightly yellow crystalline powder
Purity： 99%

Reputable Manufacturer Supply Reliable Quality 4-PHENOXYBENZOIC ACID 2215-77-2 with Safe Shipping

Molecular Formula:C13H10O3
Molecular Weight:214.221
Appearance/Colour:white to slightly yellow crystalline powder
Vapor Pressure:6.07E-06mmHg at 25°C
Melting Point:163-165 °C(lit.)
Refractive Index:1.5090 (estimate)
Boiling Point:364.2 °C at 760 mmHg
PKA:4.57(at 25℃)
Flash Point:141.7 °C
PSA：46.53000
Density:1.241 g/cm³
LogP:3.17710

4-PHENOXYBENZOIC ACID(Cas 2215-77-2) Usage

Chemical Properties	white to slightly yellow crystalline powder
Uses	4-Phenoxybenzoic acid can block DNA binding of the human papillomarvirus (HPV) E2 protein. It is employed as an intermediate of Sitafloxacin, which is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer.
Definition	ChEBI: A phenoxybenzoic acid in which the phenoxy group is para to the carboxy group.
Safety Profile	A poison by intravenous route. When heated to decomposition it emits acrid smoke and irritating vapors.

InChI:InChI=1/C13H10O3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9H,(H,14,15)/p-1

2215-77-2 Relevant articles

Suzuki?Miyaura coupling and O?arylation reactions catalysed by palladium(II) complexes of bulky ligands bearing naphthalene core, Schiff base functionality and biarylphosphine moiety

Arora, Aayushi,Kaushal, Jolly,Kumar, Arun,Nautiyal, Divyanshu,Oswal, Preeti,Singh, Siddhant

, (2022/01/19)

Schiff bases L1 [i.e., 2-(diphenylphosph...

Photoinduced FeCl3-Catalyzed Alkyl Aromatics Oxidation toward Degradation of Polystyrene at Room Temperature?

Zhang, Guoxiang,Zhang, Zongnan,Zeng, Rong

supporting information, p. 3225 - 3230 (2021/09/28)

While polystyrene is widely used in dail...

Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT

Yagci, Semih,Gozelle, Mahmut,Kaya, Selen Gozde,Ozkan, Yesim,Aksel, Ahmet Bugra,Bakar-Ates, Filiz,Dundar, Yasemin,Eren, Gokcen

, (2021/01/07)

Sirtuins (SIRTs) are a class of nicotina...

Oxidative α-C-C Bond Cleavage of 2° and 3° Alcohols to Aromatic Acids with O2at Room Temperature via Iron Photocatalysis

Zhang, Zongnan,Zhang, Guoxiang,Xiong, Ni,Xue, Ting,Zhang, Junjie,Bai, Lu,Guo, Qinyue,Zeng, Rong

, p. 2915 - 2920 (2021/05/05)

The selective α-C-C bond cleavage of unf...

2215-77-2 Process route

: 101-55-3
4-Bromodiphenyl ether

: 124-38-9,18923-20-1
carbon dioxide

: 101-84-8
diphenylether

: 2215-77-2
4-Phenoxybenzoic acid

Conditions

Conditions	Yield
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; for 10h; Ambient temperature; electrochemically;	1 mmol 86%

: 31994-68-0
4-phenoxybenzoic acid ethyl ester

: 2215-77-2
4-Phenoxybenzoic acid

Conditions

Conditions	Yield
With water; sodium hydroxide; In tetrahydrofuran; ethanol; Reflux;	89%
With water; sodium hydroxide; In ethanol; for 3h; Reflux;	87%
With sodium hydroxide; In ethanol; water; for 3h; Reflux;	75%
With water; sodium hydroxide; In ethanol; for 3h; Reflux;
With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;
With water; sodium hydroxide; In ethanol; at 80 ℃; for 1h;
With water; sodium hydroxide; In ethanol; for 3h; Reflux;

2215-77-2 Upstream products

109-72-8
n-butyllithium
101-55-3
4-Bromodiphenyl ether
60-29-7
diethyl ether
2974-94-9
4-phenoxyiodobenzene

2215-77-2 Downstream products

67031-66-7
4-phenoxy-benzoic acid-[3-(2-methyl-piperidino)-propylester]; hydrochloride
67048-35-5
4-phenoxy-benzoic acid-[3-(2r,6c-dimethyl-piperidino)-propylester]; hydrochloride
31994-68-0
4-phenoxybenzoic acid ethyl ester
1623-95-6
4-phenoxybenzoyl chloride

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2215-77-2

Quick Details

Reputable Manufacturer Supply Reliable Quality 4-PHENOXYBENZOIC ACID 2215-77-2 with Safe Shipping

4-PHENOXYBENZOIC ACID(Cas 2215-77-2) Usage

2215-77-2 Relevant articles

Suzuki?Miyaura coupling and O?arylation reactions catalysed by palladium(II) complexes of bulky ligands bearing naphthalene core, Schiff base functionality and biarylphosphine moiety

Arora, Aayushi,Kaushal, Jolly,Kumar, Arun,Nautiyal, Divyanshu,Oswal, Preeti,Singh, Siddhant

, (2022/01/19)

Photoinduced FeCl3-Catalyzed Alkyl Aromatics Oxidation toward Degradation of Polystyrene at Room Temperature?

Zhang, Guoxiang,Zhang, Zongnan,Zeng, Rong

supporting information, p. 3225 - 3230 (2021/09/28)

Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT

Yagci, Semih,Gozelle, Mahmut,Kaya, Selen Gozde,Ozkan, Yesim,Aksel, Ahmet Bugra,Bakar-Ates, Filiz,Dundar, Yasemin,Eren, Gokcen

, (2021/01/07)

Oxidative α-C-C Bond Cleavage of 2° and 3° Alcohols to Aromatic Acids with O2at Room Temperature via Iron Photocatalysis

Zhang, Zongnan,Zhang, Guoxiang,Xiong, Ni,Xue, Ting,Zhang, Junjie,Bai, Lu,Guo, Qinyue,Zeng, Rong

, p. 2915 - 2920 (2021/05/05)

2215-77-2 Process route

2215-77-2 Upstream products

2215-77-2 Downstream products

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